Rimegepant is an oral antagonist of the CGRP receptor developed by Biohaven Pharmaceuticals. It received FDA approval on February 27, 2020 for the acute treatment migraine headache. While several parenteral antagonists of CGRP and its receptor have been approved for migraine therapy (e.g. [erenumab], [fremanezumab], [galcanezumab]), rimegepant and [ubrogepant] are the only members of the "gepants" family of medications remaining in development, and the only CGRP antagonists that possess oral bioavailability. The current standard of migraine therapy involves abortive treatment with "triptans", such as [sumatriptan], but these medications are contraindicated in patients with pre-existing cerebrovascular and cardiovascular disease due to their vasoconstrictive properties. Antagonism of the CGRP pathway has become an attractive target for migraine therapy as, unlike the triptans, oral CGRP antagonists have no observed vasoconstrictive properties and are therefore safer for use in patients with contraindications to standard therapy. Rimegepant Intermediates,Rimegepant Cas 1190363-46-2,Rimegepant Cas 1373116-06-3,Rimegepant Cas 1190363-45-1 Â Shandong Haohong Biotechnology Co., Ltd. , https://www.haohongpharma.com
China Stone Crushing Plant Rock Screening Plant Stone Production Line
1. Long service life, low maintenance rate and low operation cost:Â The solid(strong) frame design, the large-diameter forged shaft,
and the main shaft with no thread and processed with sharp radius minimize stress concentration.
2. Quick to install:Â High assembly and applicability facilitate fixed and mobile structure installation. (facilitate installation for fixed
and mobile structure)
3. Easy adjustment:Â The main crusher frame is internally equipped with hydraulic wedge blocks to adjust the sizes of discharge openings.
4. Easy maintenance:Â The jaw plates are secured(fixed) by the mechanical wedge block system to prevent operators from touching
the front and rear bolts on the main crusher frame(of the main crusher).
5. Stable operation and short downtime:Â The high-precision (casting) movable jaw support plate, the toggle(rib) plate non-lubrication,
and the self aligning roller bearing and high-strength main shaft design ensure equipment stability, which is widely known in the industry.
6. Evenly distributed crushing force of jaw plates and machined jaw plate positioning.
Detailed Images
Stone Crusher Line Includes:Vibrating Feeder,Jaw Crusher,Impact Crusher,Vibrating Screen.
1.Vibrating Feeder:
Vibrating Feeder can be massive, granular materials from the bunker is continuous and uniform feeding expected by the device.In
sand production line to avoid continuous evenly feed crusher crusher blockage by mouth.
2.Jaw Crusher
cavity, the simulation of the animals two jaw crusher movement and complete material crushing operations.Widely used in mining
metallurgy, building material, highway, railway, water conservancy and chemical industry, etc all kinds of ores and large materials
in pieces.Being broken material maximum compressive strength of 320 mpa.
3.Impact Crusher
Counterattack crusher is also called back break, mainly used in metallurgy, chemical industry, building materials, water and
electricity and other materials processing, often need to move operations especially for highway, railway, water and electricity
engineering, such as liquidity stone work, according to the type of processing raw material, the requirements of different size and
finished product material using a variety of configuration forms
Vibrating screen is to use the vibrator excitation generated by the reciprocating screw type vibration and work.Stator rotating
hammer on that plane whirl vibration sieve surface, while the rotating hammer make cone rotary vibration sieve surface, the effect
of the combined complex type rotary vibration sieve surface.
Maximum feedÂ
(mm)Â
Capacity Â
(t/h)Â
Major equipments specificationsÂ
Â
Â
Feeding equipmentÂ
Coarse crushing equipment
Fine crushing equipmentÂ
Screening equipmentÂ
340Â
30Â
GZD2511(3kw)Â
PE400×600(30kw)Â
PF1007(45kw)Â
3YZ1236(11kw)Â
340Â
50Â
GZD3117(10kw)Â
PE400×600(30kw)Â
PF1007(45kw)Â
3YK1545(22kw)Â
420Â
80Â
GZD3617(10kw)Â
PE500×750(55kw)Â
PF1010(75kw)Â
3YK1548(22kw)Â
480Â
100Â
GZD4321(13kw)Â
PE600×900(75kw)Â
PF1210(130kw)Â
3YZ1548(22kw)Â
560Â
150Â
GZD4321(13kw)Â
PE750×1060(90kw)Â
PF1210(130kw)Â
3YZ1845(22kw)Â
630Â
200Â
GZD4321(13kw)Â
PE900×1060(110kw)Â
PFB1212(140kw)Â
3YZ2050(30kw)Â
630Â
250Â
GZD5027(17kw)Â
PE900×1060(110kw)Â
PFB1214(180kw)Â
3YZ2050(30kw)Â
630Â
300Â
GZD5027(17kw)Â
PE900×1200(110kw)Â
PFB1214(180kw)Â
3YZ2160(30kw)Â
700Â
350Â
GZD5027(17kw)Â
PE1000×1200(132kw)Â
PFB1315(250kw)Â
3YZ2160(30kw)Â
700Â
450Â
GZD6223(28kw)Â
PE1000×1200(132kw)Â
PFB1214/2(300kw)Â
Â
Package &Â Shipment
Â
Construction Case
Certification
Our Service
Effective communication:
Any inquiry will be fast replied. Accurately convey customer's information. Help customer to control the goods quality.
In-time and reliable after sale service:
We have been keeping a very good cooperation relationship with factories. We can help customer to change the broken spare
parts or send engineer to the local in-timely with low cost.
Warranty and after sale service:
1 year warranty. Engineer comes to the local for installation for free in the first month and free spare parts changing. If it is above
1 year, need customer charge the air tickets, visa and living expenses for the engineers to install in the local.Â
Contact UsÂ
Harbin Zephyr Trading Co., Ltd
Add: Room 501, No.209 Changjiang Road, Nangang District, Harbin city, Heilongjiang Province, China.
Contact person: Lydia Li
Web: http://hrbzephyr.en.made-in-China.com
Tel: +86 451 87002245Â Â Fax: +86 451 87000678
 Mobile:+86-159 4608 4907
Â
Â
Â
If you are interested ,Please contact with me as soon as possible.
Â
Product Description
China Stone Crushing Plant Rock Screening Plant Stone Production Line
1. Long service life, low maintenance rate and low operation cost:Â The solid(strong) frame design, the large-diameter forged shaft,
and the main shaft with no thread and processed with sharp radius minimize stress concentration.
2. Quick to install:Â High assembly and applicability facilitate fixed and mobile structure installation. (facilitate installation for fixed
and mobile structure)
3. Easy adjustment:Â The main crusher frame is internally equipped with hydraulic wedge blocks to adjust the sizes of discharge openings.
4. Easy maintenance:Â The jaw plates are secured(fixed) by the mechanical wedge block system to prevent operators from touching
the front and rear bolts on the main crusher frame(of the main crusher).
5. Stable operation and short downtime:Â The high-precision (casting) movable jaw support plate, the toggle(rib) plate non-lubrication,
and the self aligning roller bearing and high-strength main shaft design ensure equipment stability, which is widely known in the industry.
6. Evenly distributed crushing force of jaw plates and machined jaw plate positioning.
Detailed Images
Stone Crusher Line Includes:Vibrating Feeder,Jaw Crusher,Impact Crusher,Vibrating Screen.
1.Vibrating Feeder:
Vibrating Feeder can be massive, granular materials from the bunker is continuous and uniform feeding expected by the device.In
sand production line to avoid continuous evenly feed crusher crusher blockage by mouth.
2.Jaw Crusher
cavity, the simulation of the animals two jaw crusher movement and complete material crushing operations.Widely used in mining
metallurgy, building material, highway, railway, water conservancy and chemical industry, etc all kinds of ores and large materials
in pieces.Being broken material maximum compressive strength of 320 mpa.
3.Impact Crusher
Counterattack crusher is also called back break, mainly used in metallurgy, chemical industry, building materials, water and
electricity and other materials processing, often need to move operations especially for highway, railway, water and electricity
engineering, such as liquidity stone work, according to the type of processing raw material, the requirements of different size and
finished product material using a variety of configuration forms
Vibrating screen is to use the vibrator excitation generated by the reciprocating screw type vibration and work.Stator rotating
hammer on that plane whirl vibration sieve surface, while the rotating hammer make cone rotary vibration sieve surface, the effect
of the combined complex type rotary vibration sieve surface.
Maximum feedÂ
(mm)Â
Capacity Â
(t/h)Â
Major equipments specificationsÂ
Â
Â
Feeding equipmentÂ
Coarse crushing equipment
Fine crushing equipmentÂ
Screening equipmentÂ
340Â
30Â
GZD2511(3kw)Â
PE400×600(30kw)Â
PF1007(45kw)Â
3YZ1236(11kw)Â
340Â
50Â
GZD3117(10kw)Â
PE400×600(30kw)Â
PF1007(45kw)Â
3YK1545(22kw)Â
420Â
80Â
GZD3617(10kw)Â
PE500×750(55kw)Â
PF1010(75kw)Â
3YK1548(22kw)Â
480Â
100Â
GZD4321(13kw)Â
PE600×900(75kw)Â
PF1210(130kw)Â
3YZ1548(22kw)Â
560Â
150Â
GZD4321(13kw)Â
PE750×1060(90kw)Â
PF1210(130kw)Â
3YZ1845(22kw)Â
630Â
200Â
GZD4321(13kw)Â
PE900×1060(110kw)Â
PFB1212(140kw)Â
3YZ2050(30kw)Â
630Â
250Â
GZD5027(17kw)Â
PE900×1060(110kw)Â
PFB1214(180kw)Â
3YZ2050(30kw)Â
630Â
300
Model NO.: PV/PF/ZSW
Finished Surface: Thread Process
Certification: CE, ISO
Condition: New
Color: Custom
Warranty: 12 Months
Power(W): 423kw
Dimension: 16.9m*2.8m*3.5m
Weight: 38.3t
Installation: Engineer Guide
MOQ: 1PC
Discharging: Can Be Adjusted
Structure&Cost: Simple and Low
After-Sales Service: Engineers Available to Service Machinery Overseas
Move Type: Fixed or Portable
Trademark: Other
Transport Package: to Transport by Sea
Specification: Depend On Type
Origin: China
HS Code: 8474209000
Model NO.: PV/PF/ZSW
Finished Surface: Thread Process
Certification: CE, ISO
Condition: New
Color: Custom
Warranty: 12 Months
Power(W): 423kw
Dimension: 16.9m*2.8m*3.5m
Weight: 38.3t
Installation: Engineer Guide
MOQ: 1PC
Discharging: Can Be Adjusted
Structure&Cost: Simple and Low
After-Sales Service: Engineers Available to Service Machinery Overseas
Move Type: Fixed or Portable
Trademark: Other
Transport Package: to Transport by Sea
Specification: Depend On Type
Origin: China
HS Code: 8474209000
Product DescriptionJaw crusher common jaw broken, also known as the tiger mouth.Consists of two piece of jaw, moving jaw and static jaw crushing
4.Vibrating Screen
Jaw crusher common jaw broken, also known as the tiger mouth.Consists of two piece of jaw, moving jaw and static jaw crushing
4.Vibrating Screen